Cytokine Therapy for Inhibition of DHT-Induced Hair Loss and Normalization of the Anagen Phase

How AesMed’s AGF39™ Supports Hair Regeneration

Hair loss is a common issue affecting millions of people worldwide.
Among its many causes, dihydrotestosterone (DHT) is one of the primary contributors to thinning hair and both male and female pattern baldness.


DHT interferes with the mRNA transcription of follicular cells, halting hair protein synthesis, inducing the catagen (regression) phase of the hair cycle, and stimulating the secretion of cytokines that lead to cell apoptosis. This ultimately leads to follicular miniaturization and the cessation of hair production.


This is where AGF39™ by AesMed offers an innovative solution by correcting the cytokine imbalance caused by DHT, thereby inhibiting hair loss and restoring the hair cycle to its healthy anagen (growth) phase.

Understanding the Role of DHT in Hair Loss

DHT is an androgen a male hormone reduced derived from testosterone through the action of 5-α-reductase and binds to androgen receptors in hair follicle
Over time, DHT triggers a cascade of intracellular gene expressions and signaling processes that lead to follicular miniaturization, ultimately resulting in hair loss.
This process is especially common in individuals experiencing androgenetic alopecia, affecting both men and women.



What Is AGF39™ and How Does It Work?


AGF39™ is an advanced mesotherapy solution that combines seven high-concentration, potent cytokines—KGF, IGF-1, VEGF, bFGF, Noggin, FGF9, and SOD.
These natural proteins play critical roles in regulating cellular functions, including hair growth.
AGF39™ is specifically designed to correct DHT-induced cytokine imbalances in the hair follicles, suppress the effects of DHT, and promote the regeneration of healthy follicles.

Therapeutic Effects

  1. Recovery of Cytokine Imbalance and Inhibition of Follicular Damage:
    Key components like FGF9, SOD, and Noggin suppress the activity of DKK-1, TGF-β, and BMP—catagen-inducing and cell-apoptotic cytokines triggered by DHT.
    FGF9, SOD and Noggin inhibit signaling pathways that lead to follicular miniaturization, preventing follicular shrinkage and promoting healthy follicular growth.
  2. Restoration of Hair Growth Cycle:
    AGF39™ helps restore cytokine balance within follicular cells, preventing the transition of anagen follicles into the catagen phase and stimulating telogen follicles to re-enter the anagen phase—essential for healthy hair regeneration.
  3. Stimulation of Follicular Regeneration:
    Cytokines such as IGF-1, bFGF, KGF, and VEGF promote angiogenesis, differentiation, and proliferation within follicular cells. They enhance scalp microcirculation and protein synthesis, supplying vital nutrients for follicle regeneration and growth.
  4. Activation of Cellular Energy Metabolism and Inflammation Reduction:
    AGF39™ includes AHK-cu, 18 amino acids, 10 types of vitamins, essential minerals, coenzymes, glutathione, and adenosine triphosphate—34 essential nutrients that stimulate the energy metabolism of follicular cells.
    SOD (Superoxide Dismutase) acts as a powerful antioxidant, reducing oxidative stress on the scalp and improving the overall environment for hair growth.

Proven Effectiveness of AGF39™


AesMed’s AGF39™ has undergone rigorous clinical trials and demonstrated proven effectiveness in treating DHT-induced hair loss.
Studies have shown that patients treated with AGF39™ experience significant improvements in hair density and follicle thickness.
This treatment not only prevents hair loss but also stimulates new hair growth, restoring fullness and volume.

Why Choose AGF39™?


Unlike conventional treatments that merely mask symptoms, AGF39™ targets the root cause at the cellular level.
By combining advanced cytokine science with professional mesotherapy techniques, AGF39™ offers a highly effective and safe solution for individuals suffering from DHT-related hair loss.

Key Benefits of AGF39™ Include:


• Targeted therapy against DHT-induced hair loss
• Safe, non-hormonal solution with minimal side effects
• Clinically proven results across multiple studies
• Suitable for both men and women with androgenetic alopecia
• Rapid and noticeable results with continued use

AGF39™ Treatment Protocol


AGF39™ is typically administered via mesotherapy, using fine, pain-free needles to inject the solution into the scalp’s superficial dermis layer.
The concentration of cytokines can be adjusted to suit individual needs for optimal results. Treatments are generally performed every 2 to 4 weeks, depending on the severity of hair loss.
After each session, special shampoos and post-treatment products are recommended to maximize hair regrowth and maintain scalp health.


Conclusion

If you are struggling with DHT-induced hair loss and looking for a solution that targets the root cause, AesMed’s AGF39™ is your best choice.

Don’t let DHT block your hair’s future.
Discover the power of AGF39™ and take your first step toward hair regeneration today.

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